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Protein Structure Prediction
John Moult
The task of computing protein structure starting from amino acid sequence
has been a ´Grand Challenge' problem in computational biology for over
thirty years.
Although much progress has been made, and it is now possible to generate
approximate models for many proteins, we still do not have general methods
of producing accurate structures.
CASP, a community wide system of experiments to measure the performance
of prediction methods, has provided a large body of data on what methods
work, what don^t, and, in particular, what obstacles stand between
us and a more complete solution.
In this talk, I will use these data to identify the strengths and
limitations of present prediction techniques, and suggest strategies that
will overcome the remaining obstacles.
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