Tumor cells exhibit a high degree of variability in terms of morphology, phenotype, metastatic potential and underlying molecular profile. This heterogeneity is present not only across different patients (inter-tumor heterogeneity) but also within the same tumor (intra-tumor heterogeneity) and has emerged as an inherent property of cancer.
Identifying the sources of heterogeneity and its implications in clinical outcomes, such as response to therapy or ability to metastasize, has become a cornerstone for the development of effective disease management strategies.
Our work was recently published in Cell. You can read about it here.
Four levels of tumor heterogeneity.
Courtesy of Florian Markowetz, posted on Science B-Sides.